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lactate dehydrogenase elevating virus
Lactate dehydrogenase elevating virus, or LDV for short, belongs to part of the arteriviridae family and the nidovirales order. Also included in the nidovirales order are the coronaviridae. The arteriviridae infect macrophages in animals and cause a variety of diseases. LDV specifically causes lifelong persistent viremia in mice, but doesn’t really harm the host and only slightly harms the immune system. The main clinical sign is an increased level of the plasma enzyme lactate dehydrogenase (LDH). LDV has a remarkably narrow cell type specificity, meaning nothing homologous with LDV in mice has been found in another species.
==Discovery==
LDV was discovered in 1960 by Dr. Vernon Riley and his colleagues while they were working with plasma enzymes in tumor-bearing mice. They found that many types of transplantable tumors caused a five to tenfold increase in the plasma lactate dehydrogenase (LDH) activity within three days of the transplantation. This occurred even before the tumors were obvious clinically. In further investigations they found that cell-free plasma from tumor-bearing mice was sufficient to cause this increase, which indicated that the agent was small and further investigation showed that it was a virus.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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